Biology of Reproduction Summers |
Endocrinology Homeostasis/Feedback Adult Female Steroid Production Ovulation |
Adult Male Gonadal Axis Regulation Sexual Differentiation Sexual Behavior Puberty |
Reproductive Cycling Estrous Cycles Menstrual Cycle Menopause Fertilization |
Fertilization Systems Gamete Interaction Pregnancy Labor and Parturition Lactation |
Sexual Response & Behavior Pheromones STDs text: Human Reproductive Biology2nd Edition- RE Jones & KH Lopez,: pp 24-28 Acronyms/Abbreviations end |
VIII. Steroid Production A. one of the 1o functions of follicle cells B. Estrogens: any compound that causes the uterus to grow 1. 3 natural endogenous estrogens a. E2 = estradiol-17b b. E1 = estrone c. E3 = estriol 2. environmental estrogens may come from plants or degradation of industrial biochemicals like pesticides C. Progestogens: any compound that allows embryo to implant/grow in the uterus 1. P (progesterone) (peripheral) 2. in the brain a. THP = allopregnanolone = 3a-OH-DHP b. Preg-S = pregnenolone sulfate D. Androgens: any compound which will stimulate growth of the seminal vesicles 1. potent: most common in men a. T = testosterone b. DHT = dihydrotestosterone 2. weak androgens: measured most commonly in women a. DHEA = dehydroepiandosterone b. androstenedione E. steroidogenesis cholesterol ¯ pregnenolone ¯ 17-hydroxypregnenolone ¯ DHEA ® androstenedione 1. D5 pathway = ® = main follicular source of steroids from the ovay a. Tertiary follicles Theca Granulosa *LH cholesterol ® ® pregnenolone D5 ¯ ¯ transported by diffusion androstenedione- - - - - - - - - ® ¯ T ¯ ¯ *FSH *required E2 F. Corpus Luteum (yellow body) 1. formed after ovulation 2. Luteinization a. product of LH surge (name of LH) i. begins just before ovulation b. theca thickens c. granulosa divides (mitosis) i. very fast d. these cells now = luteal cells e. steroidogenic - D4 pathway = ® cholesterol ¯ D4 pregnenolone ® ® ® ® ® ® Progesterone ¯ ¯ 17-OH-preg 17-OH-P ¯ ¯ DHEA ® ® ® ® ® ® ® ® androstenedione Theca Luteal cells (granulosa) D5 cholesterol ® pregnenolone ¯ ¯ D4 P ® blood (most) ¯ ¯ (small amt) 17-OH-P ¯ andro ¯ E1 ® E2 f. 3o follicle = 1/4 P : 3/4 E2 i. E2 stimulates LH surge via + feedback ii. \ luteinization g. Corpus luteum = 2/3 P : 1/3 E2